Abstract EPAC1. a cAMP-activated GEF for Rap GTPases. is a major transducer of cAMP signaling and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the current model of EPAC1 activation in the cytosol. https://missouriquiltcoes.shop/product-category/poly-fil-stuffing/