The ubiquitin proteasome system (UPS). particularly its deubiquitinating enzymes (DUBs). play a key role in the replication cycle of coronaviruses. The SARS-CoV-2 papain-like protease (Plpro) is known to process the viral polyproteins to form the replicase transcriptase complex and to counteract the host viral response. https://missouriquiltcoes.shop/product-category/bias-tools/
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