Ginkgo biloba leaves extract (GBE) was subjected to neuroprotective-guided fractionation to produce eleven fractions with different polarities and constituents. The intermediate polar fraction was shown to be terpene trilactones-enriched fraction (TEGBE). Out of this fraction. pure ginkgolide B (G-B) was further purified and identified based on its spectral data. https://www.herbsdailyes.shop/product-category/skin-lighteners/