We have recently generated a novel medulloblastoma (MB) mouse model with activation of the Shh pathway and lacking the MB suppressor Tis21 (Patched1+-Tis21KO). ts main phenotype is a defect of migration of the cerebellar granule precursor cells (GCPs). By genomic analysis of GCPs in vivo. we identified as drug target and major responsible of this defect the down-regulation of the prom... https://www.freaknleather.com/product-category/inspection-mirror/