Purpose: Combination of benzoyl peroxide (BPO) with topical antibiotics can lead to higher efficacy and less bacterial resistance. but it in turn increases adverse effects such as skin irritability and dryness. In this study. the efficacy of combination therapy of niosomal BPO 1% and clindamycin (CL) 1% is compared with niosomal CL in acne vulgaris. https://www.parisnaturalfoodes.shop/product-category/centaury/